Separation and Identificationof Isomeric Glycopeptidesby High Field Asymmetric Waveform Ion Mobility Spectrometryzaterdag 11 februari 2012 02:28:00
AbstractThe analysis of intact glycopeptides by mass spectrometry is challenging due to the numerous possibilities for isomerization, both within the attached glycan and the location of the modification on the peptide backbone. Here, we demonstrate that high field asymmetric wave ion mobility spectrometry (FAIMS), also known as differential ion mobility, is able to separate isomeric O-linked glycopeptides that have identical sequences but differing sites of glycosylation.
Quantitative Analysisof Liquids from Aerosols andMicrodrops Using Laser Induced Breakdown Spectroscopyzaterdag 11 februari 2012 02:28:00
AbstractLaser induced breakdown spectroscopy (LIBS) is shown to be capable of low volume (90 pL) quantitative elemental analysis of picogram amounts of dissolved metals in solutions. Single-pulse and collinear double-pulse LIBS were investigated using a 532 nm dual head laser coupled to a spectrometer with an intensified charge coupled device (CCD) detector.
Infrared Multiple PhotonDissociation Spectroscopyand Computational Studies of O-Glycosylated Peptideszaterdag 11 februari 2012 02:28:00
AbstractThe infrared multiple photon dissociation (IRMPD) spectra of O-glycosylated peptides in the gas phase were studied in the IR scanning range of 5.7"9.5 μm. Fragmentation of protonated and sodiated O-glycopeptides was investigated using electrospray ionization (ESI) Fourier-transform ion cyclotron resonance (FTICR) mass spectrometry (MS) with a free electron laser (FEL). FEL is used in the IRMPD technique as a tunable IR light source.